Methadone-Associated Mortality: Report of a National Assessment

Table of Contents

Preface and related information

Conference Papers

Part 1. Purpose of the National Assessment

Part 2. Background

• Methadone's Pharmacology and Mechanisms of Action
• Methadone's Safety Profile
• National Data on Methadone Use and Associated Mortality
• State-Level Data on Methadone Use and Associated Mortality

Part 3. Deliberations

Part 4. Findings

• Recent Increases in Methadone Use Are Related to Its Use as an Analgesic
• Increases in Methadone-Associated Mortality Also Are Related to Its Use as an Analgesic
• OTPs and the Revised Federal Regulations Are Not Significant Contributors to Methadone-Associated Mortality

Part 5. Recommendations

• Uniform Case Definitions Should Be Established
• Standards for Toxicologic Testing Are Needed
• More Useful Data Are Needed
• Health Professionals Need Better Training in Addressing Pain and Addiction
• Public Misperceptions About Methadone Must Be Addressed
• Public Policies Must Respond to Multiple Needs

Part 6. Conclusions

Part 7. References and Bibliography

Part 8. Appendices

• Appendix 1. Participants in the National Assessment
  
• Appendix 2. Agenda
  
• Appendix 3. Epidemiologic Databases Consulted
• Appendix 4. Past Investigations of Methadone-Associated Mortality
• Appendix 5. Methadone Serum Level Conversion Factors
• Appendix 6. MedWatch Form
• Appendix 7. PedTox Case Report Form (from NAME)
• Appendix 8. Methadone Identified in Laboratory Testing

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